Alpha-Mangostin and Gamma-Mangostin Isolated from Mangosteen (Garcinia mangostana L.) as Promising Candidates against SARS-CoV-2: A Bioinformatics Approach

The world is endangered by the COVID‐19 pandemic caused SARS‐CoV‐2, people are dying in thousands every day, and without an actual treatment, it seems that bringing this global health problem to a quit impossible. Natural products have been constant use since ancient times proven time be effective. Medicinal plants from Indonesia may lead discovery of novel drugs. Mangosteen or Garcinia mangostana L. native tropical fruit Southeast Asia known contain bioactive compounds. Interestingly, main xanthone derivatives alpha-mangostin gamma-mangostin, these compounds variety pharmacological activities such as antiviral activity. In summary, study showed potential benefits gamma-mangostin isolated mangosteen against SARS-CoV-2. Thus, exhibits valuable plant candidate for future drug development fight However, further trials, vitro vivo evaluation, needed prove validity findings